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phenobarbital will increase toxicity of ifosfamide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe. CYP3A4 inducers may perhaps boost the metabolism of ifosfamide to its Lively alkylating metabolites.Utilization in Pregnancy. Barbiturates may cause fetal hurt when administered to a pregnant woman. Retrospective, case-m